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Tirzepatide is optimized for GIP and GLP-1 receptor engagement with minimal glucagon-receptor activity, while retatrutide retains GLP-1 and GIP affinity but introduces substitutions that restore meaningful glucagon-receptor binding

However, it should encourage us to temper our excitement about this class of drugs and to recognize that addiction is not solely a neurobiological phenomenon.

How much weight loss you lose while taking semaglutide depends on your original body weight and your response to the medication

This 7-day GLP-1 meal plan is packed with high-protein, fibre-rich, easy-to-make recipes to help you feel your best while losing weight