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The cDNA of this variant was cloned from active muscle and characterized as an autocrine factor that is, one that acts on or near the cell that produces it distinguished from the liver-derived, endocrine IGF-1 that has a systemic mode of action

Some support derives from frustrations with conventional medicines blind spots, profit motives, and the experience many patients have of being told their chronic pain or slow-healing injury is something they simply have to live with