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Avoiding foods that are high in fat, spicy, or have strong odors may also help, as these can exacerbate gastrointestinal discomfort

Participant sex was not considered in the study design

This is mechanistically distinct from taking exogenous melatonin

This study aims to perform proteomic analysis to observe the relationship between autophagy proteins and DKD, and to establish a model of high glucose-induced HK2 cell to explore and clarify the regulatory mechanisms of PERK/ATF4 axis on ATG4B autophagic pathway