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However, all applications should be considered experimental pending additional clinical research

However, these findings occurred at exposures significantly higher than therapeutic human doses, and their clinical relevance remains uncertain Case reports submitted to adverse event databases suggested a possible association between GLP-1 therapy and acute pancreatitis Theoretical mechanisms were proposed, including chronic pancreatic stimulation and potential effects on pancreatic ductal cells It is important to understand that pancreatic cancer is relatively rare but carries a poor prognosis, with a five-year survival rate of approximately 510%

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Safety depends on: Personal medical history Thyroid cancer history Pancreatitis history GI sensitivity Cardiovascular risk profile Both carry boxed warnings regarding thyroid C-cell tumors observed in animal studies