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Flavonoids, including isoorientin, catechin, coumaric acid and kaempferol-7-O-D-glucuronide, derived from Gentiana (56), Phyllostachys nigra (57), Cryptotaenia japonica (57) and dried pomegranate concentrate powder (58) exhibit skin-whitening effects by downregulating PKA/CREB-mediated MITF expression

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As a result, most reports lack sufficient procedural detail to allow reproducible clinical implementation, and meaningful comparison across studiesparticularly those using different biologic agents such as platelet-rich plasma (PRP), extracellular vesicles (EVs), or scaffold-based platformsremains difficult

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