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Skeletal muscle and heart may also accumulate considerable amounts of iron as is noted in brain, liver and other tissues, and there is evidence that increased iron storage correlates with ROS formation in tissues (Yoshiji et al., 1992

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However, certain periodontal pathogens, including Porphyromonas gingivalis , Klebsiella , Helicobacter pylori , Streptococcus , Veillonella , Parvimonas micra , and Fusobacterium nucleatum can endure harsh acidic environments and migrate to the intestine 24 , particularly in individuals with reduced gastric acid levels, such as those using proton pump inhibitors (PPIs) 25

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