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When the food is swallowed, a substance in saliva called R-protein a protein that protects B12 from being destroyed by stomach acid travels to the stomach along with the food

In addition to viral replication, these proteins can trigger responses and induce cytotoxic and pro-inflammatory effects in neurons, dendritic cells (DCs), microglia, and macrophages, and astrocyte across the CNS, thereby contributing to the development of NeuroHIV [35,36,37]