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These effects are typically mild to moderate, most pronounced during dose escalation, and diminish as the body adjusts to the medication

If a protocol adds frequency or increases dose without a clear reason, the study may stop testing a clean pulse-based design and start testing accumulation of procedural stress

Dietary supplements, including green tea extract (particularly when standardized to have a high catechin concentration) and kava, black cohosh, high-dose curcumin, and some Chinese herbal preparations, are implicated in hepatocellular injury, cholestasis, or fulminant hepatic failure in both single case reports and small clinical series

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