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STEP trials show GLP-1 works for weight loss The STEP program (Semaglutide Treatment Effect in People with Obesity) was a series of large, global clinical trials that first showed semaglutide could cause major weight loss (even in people without diabetes)

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Abstract Glucagon-like peptide-1 (GLP-1) is an incretin peptide hormone mainly secreted by enteroendocrine intestinal L-cells