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doi: 10.1016/j.cmet.2016.05.006

Not many anti-diabetic agents have the potential to decrease the patients risk factors for cardiovascular disease and some may even cause the patient to gain weight leading to other co-morbidities

Individuals with one or two copies of the genetic variation and low activity of the MTHFR enzyme may present with elevated homocysteine levels, which have been associated with inflammation, heart disease, pregnancy complications, and even miscarriages

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