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Using combination therapies to target critical downstream signaling pathways is considered a rational approach

Cell Mol Life Sci 2016;73:234967 [DOI] [PMC free article] [PubMed] [Google Scholar] 55.Manakkat Vijay GK, Ryan JM, Abeles RD, Ramage S, Patel V, Bernsmeier C, Riva A, McPhail MJ, Tranah TH, Markwick LJ, Taylor NJ, Bernal W, Auzinger G, Willars C, Chokshi S, Wendon JA, Ma Y, Shawcross DL.Neutrophil toll-like receptor 9 expression and the systemic inflammatory response in acetaminophen-induced acute liver failure

doi:10.1134/s2079057019030147

Through longitudinal follow-ups of large samples, research teams have quantified changes in the frequency and severity of high altitude illnesses at different altitudes, providing key data for risk prediction models