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"SURMOUNT-1: Tirzepatide Once Weekly for the Treatment of Obesity." ACC.org Wilding JPH, et al

Yes, switching between peptides is possible and sometimes beneficial

Semaglutide works by: Slowing gastric emptying, which prolongs the feeling of fullness after meals Acting on appetite centres in the brain to reduce hunger and food intake Enhancing glucose-dependent insulin secretion from pancreatic beta cells Suppressing inappropriate glucagon release These combined effects typically result in reduced caloric intake and consequent weight loss