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Commonly reported side effects for this medication class include nausea, vomiting, diarrhea, and constipation, along with more serious considerations such as pancreatitis risk, thyroid C-cell tumor boxed-warning language, and contraindications for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2

Layered clothing is the most effective immediate intervention, allowing adjustment to varying environmental temperatures throughout the day