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In addition, Fer-1 alleviated DN and ameliorated renal hypertrophy and albuminuria by inhibiting ferroptosis, and ultimately reduced the accumulation of intracranial lipid peroxides in diabetic mice through the HIF-1/HO-1 pathway [242]

1, RA (as a fat-soluble compound) is transported directly through the cell membrane and in cytosol binds to cellular retinoic acid binding protein (CRABPII), which subsequently transfers RA to the nucleus