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Overall, we think this is an acceptable profile & orfo[rglipron] 36 mg generally looks in line vs Wegovy 2.4 mg/oral sema[glutide] 50 mg, Akash Tewari, global head of biopharmaceutical research with Jefferies, wrote in a research note

323 Isotopic tracer studies have shown that MAFLD patients exhibit increased de novo lipogenesis (DNL), that is respectively mediated by two transcription factors SREBP-1c and ChREBP