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Moreover, the superiority, in terms of reduction of cardiovascular events with the use of GLP-1RAs as compared to DPP4i found in different studies, not only reinforce the current recommendations of guidelines, but also advocate for the urgent need to change prescription patterns of GLMs, where DPP4i are still largely more used than GLP-1RAs

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They mimic natural GLP-1 but last much longer in the body, providing more sustained effects on blood sugar control and appetite regulation

Importantly, these effects occur without activation of growth hormone receptor pathways or alteration of IGF-1 signaling, allowing AOD 9604 to be used as a tool for isolating metabolic signaling mechanisms