12 GhGPX genes had been identified and which were represented putative GhGPX1, GhGPX2, GhGPX3, GhGPX4, GhGPX5, GhGPX6, GhGPX7, GhGPX8, GhGPX11, GhGPX12, GhGPX13 and CotAD_39521
63 Together, these findings indicate that (i) the sensitivity of tumors to insulin and IGF-1 parallels their response to CR, and (ii) neither the activation status of PI3KAKT per se nor mutation status of individual genes predicts for the sensitivity of tumors to both growth factors and CR
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This mechanism has been associated, in experimental settings, with changes in tissue oxygen availability and cellular metabolic processes