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In retatrutide trials specifically, starting at 4 mg instead of 2 mg nearly doubled early GI symptom rates

10.1002/cne.902110304 J

As we age, the natural production of these peptides declines, contributing to common signs of aging and slower recovery

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Nencioni L., Iuvara A., Aquilano K., Ciriolo M.R., Cozzolino F., Rotilio G., Garaci E., Palamara A.T