Their production is well reported, including Gram-positive and Gram-negative bacteria through the enzymatic degradation of tryptophan ( Figure 1 ), and different indole analogs are produced such as 3-methylindole (skatole), indoxyl sulfate, indole-3-propionic acid, indole-butyric acid (Martnez-Morales et al., 2003
However, the mechanism remains unclear
24,25 Medication sensitivity also presents a common barrier to medications when they are tried, deterring both patients and clinicians from pursuing additional treatment

Disclosure of interest: Seyyed Sina Hejazian: nothing to disclose - Alireza Vafaei Sadr: nothing to disclose - Ajith Vemuri: nothing to disclose - Vida Abedi: nothing to disclose - Ramin Zand: nothing to disclose E-Posters - RECOVERY, REHABILITATION AND OUTCOME 03.00 - RECOVERY, REHABILITATION AND OUTCOME - 03.02 - LIFE AFTER STROKE P2228 - ESOC25-911 NEUROPSYCHIATRIC SEQUELAE AND COGNITIVE DEFICITS AFTER STROKE WITH THROMBECTOMY AND GOOD FUNCTIONAL OUTCOME (NESCAT): PRELIMARY RESULTS Naomi Giesers 1,2 , Constanze Buschmann 3 , Mandy Roheger 3 , Rachana Mahadevan 3 , Karsten Witt 1,2 , Thomas Liman 1,2,4 1 Neurology, Carl von Ossietzky-University Oldenburg, Oldenburg, Germany, 2 Evangelical Hospital Oldenburg, Oldenburg, Germany, 3 Department of Psychology, Carl von Ossietzky University Oldenburg, Oldenburg, Germany, 4 Charit, Berlin, Germany Background and Aims: Endovascular thrombectomy (EVT) significantly improves functional recovery following stroke, but cognitive deficits and neuropsychiatric sequelae in patients with favorable outcomes remain underexplored
