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The gap goes back to how Part D (the part of Medicare that covers medication) was written when drug coverage began in 2006

Although native healthy NP tissue has a higher ratio of proteoglycan to collagen and more water content than fibrotic tissue, which consists mainly of fibrocartilage, the ability of fibrosis alone to maintain the IVD height may alleviate pressure on sensitive tissues and restore the biomechanical function of IVDs, as we have shown with our biomechanical testing

Differentially expressed mitochondrial genes were also observed in astrocytes