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In sum, it is worthy to note that lipid peroxidation (LPO) products such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) arise as secondary messengers of oxidative stress, which is often counterbalanced by the cellular antioxidant defense system [133]

Gastroenterology 97:853- 859, 1989 Olson CE: Glutathione modulates toxic oxygen metabolite injury of canine chief cell monolayers in primary culture

Moreover, certain medications, including metformin, proton pump inhibitors, and antacids may also reduce your bodys ability to absorb vitamin B12 from your diet (1, summary Vitamin B12 deficiency can manifest itself through a variety of symptoms