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Tirzepatide, a dual GLP-1/GIP receptor agonist, produces 2025% body weight reduction in clinical trialssubstantially more than phentermine alone and comparable to or exceeding Zepbound in head-to-head comparisons

These medications slow stomach emptying, which can increase the risk of aspiration during anesthesia

During widespread supply shortages last year, many of these companies including Hims and Ro - sold compounded versions of the drugs at steep discounts

It's not appropriate for everyone, for example, it's generally not recommended for women with PCOS (who already have elevated androgens) or for those without evidence of diminished ovarian reserve