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Von Willebrand Disease (VWD) illustrated how real-world data can bridge the gap between symptoms and diagnosis, helping clinicians identify diagnostic delays, quantify disease burden, understand patient journeys, and generate evidence that supports more timely, personalized, and patient-centered care

For many people, the diagnosis comes with a frustrating reality: stubborn weight gain , fatigue, insulin resistance, and metabolic slowdown that does not respond well to diet and exercise alone

doi: 10.1007/s11064-021-03335-9 142

To further confirm this potential shift in the conformational equilibrium, we collected a second cryo-EM dataset for Cagri-CTR ( N = 2) from a separate protein purification