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Moreover, single-nucleus RNA sequencing of postmortem ALS spinal cords identified glial populations enriched for inflammatory and activation-associated markers, many of which converge on RIPK1 signaling and necroptotic cell death pathways (Zelic et al., 2025)

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In conclusion, although preclinical evidence strongly supports the neuromodulatory role of GLP-1R signaling in reducing psychostimulant-induced behaviors, further research is required to refine our understanding of sex-specific effects, long-term efficacy, pharmacodynamic targets, and translational applicability

Shimada BK, Swanson S, Toh P, Seale LA