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Aborted LR3 clinical studies in oncology (late 1990s) highlighted the complexity of IGF-1R targeting: mitogenic potential on mammary and prostate tumor lines, requiring abandonment of development in favor of IGF-1R antagonists (monoclonal antibodies such as figitumumab, ganitumab, dalotuzumab) which also encountered phase III failures but enriched understanding of the IGF axis role in carcinogenesis

The term nutraceutical was coined by DeFelice in 1989 from the words nutrition and pharmaceutical and is defined as a food or part of a food that provides medical or health benefits, including the prevention and treatment of a disease

It can be applied on clean, dry skin before makeup, or throughout the day for touch-ups over makeup as needed

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