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For many people, the diagnosis comes with a frustrating reality: stubborn weight gain , fatigue, insulin resistance, and metabolic slowdown that does not respond well to diet and exercise alone

While researchers are making strides in understanding the exact structure of the carnitine transporter protein, these discoveries have not yet led to clinical gene therapy or gene-editing trials [5]

They lower blood sugar after meals, slow how fast the stomach empties, and act on appetite centres in the brain which is why they reduce hunger and are now licensed for weight loss as well as type 2 diabetes

2a, b), although they were decreased in frequency and numbers (Supplementary Fig