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Larger trials on more diverse populations are needed [28]

Rights reserved 7 SCIENTIFIC REPORTS | (2019) 9:19437 | www.nature.com/scientificreports www.nature.com/scientificreports/ stress and drug eects, stress eect p = 0.007), Adrb3 expression being higher aer SIH in WIN 64338-injected mice compared to non-stressed mice that received WIN 64338 (post-hoc WIN 64338 vs WIN 64338 + SIH, p = 0.013) (Fig.6b)

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Key Takeaways GHK-Cu (Copper Tripeptide-1) at 1 to 5 percent concentration shows measurable collagen I and III upregulation in fibroblast studies, but human RCT data are limited to small cosmetic trials