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Emibetuzumab (LY2875358) against c-Met and HGF and MP0250 against HGF and VEGF are two bispecific antibodies that prevent c-Met attachment to the ligand, increase the internalization, destroy c-Met molecules, and thereby reduce the signaling of the c-Met pathway [149, 174, 175]

The proteins responsible for chromosomal adhesion form a circular complex, comprising Smc1, Smc3, Mcd1, Scc1, and Rec8, which induces chromosome condensation (18)