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In the cholesterol biosynthesis pathway, expression of genes such as lanosterol synthase ( Lss ), cytochrome P450, family 51 ( Cyp51 ), NAD(P) dependent steroid dehydrogenase-like ( Nsdhl ) and 7-dehydrocholesterol reductase ( Dhcr7 ) were decreased

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These observations may be due in part to the improved oxygenation and normalization of erythropoietin production observed with SGLT2i (79) and observed renoprotective effects (80)

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