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Peak weight loss acceleration occurs during the dose-titration phase (weeks 4-20), with clinical trial data showing an average loss of 15-22% of baseline body weight by week 20

A: Retaglutide stimulates GLP-1, GIP, and Glucagon receptors simultaneously, while Semaglutide activates only GLP-1

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3,4 It is estimated that the annual global health care spending on diabetes among people aged 2079 was US$ 966 billion in 2021, and is estimated to reach more than $1054 billion by 2045