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CLINICAL PRACTICE CONSIDERATIONS Long-term outcomes While strong evidence supports the kidney-protective effects of both SGLT2 inhibitors and GLP-1 receptor agonists, the long-term durability of these benefits remains uncertain (Table 2)

Tirzepatide therapy involves titrated dosing, which means your dose is gradually increased over time to minimize side effects and optimize results

No direct stack RCT has evaluated the combination in humans

Those with certain FTO or MC4R variants may achieve sufficient results with semaglutide's single mechanism, particularly if they prefer a gentler introduction to GLP-1 therapy