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There are several options for skin lightening treatments, from over-the-counter or prescription bleaching creams to expensive laser treatments and chemical peels

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The secondary efficacy endpoint was the proportion of subjects achieving complete (melasma score 0) or near-complete (melasma score 1) clearing by Week 8

The overuse and misuse of antibiotics further speed up the phenomenon as the bacteria can evade the effects of these drugs by applying selection pressure on them and allowing resistance genes to spread and enhance the resistance of the microbial communities in Fig