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Sensitivity to platinum-based chemotherapy drugs was then compared in A2780 and A2780/GSTP1 cells and significant differences in chemosensitivity observed following treatment with cisplatin (2.28-fold decrease in IC 50, P =0.03, Figure 2B) and carboplatin (4.83-fold decrease in IC 50, P =0.007, Figure 2C), and a less pronounced decrease in sensitivity to paclitaxel (1.58-fold increase in IC 50, P =0.02, Figure 2D)
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You might have seen scary headlines about sunscreen getting into your blood
In addition, mRNA expression of key genes in lysosomes, including acid hydrolases (such as cathepsin A/D), LAMP-1 and LAMP-2, was significantly upregulated following sepsis, hinting that overloaded lysosomal function might be an early marker for poor outcomes for patients with sepsis 22
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