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It fluctuates within organs (rest vs activity, fasting vs fed, waking vs sleeping), and is different in each organ
The human CAT and the TGF- receptor were selected as potential targets
However, challenges such as the assurance of long-term safety, standardization of manufacturing processes, and establishment of sophisticated preclinical models reflecting the human skin environment must be resolved
doi: 10.3389/fmolb.2021.765970 Received 27 August 2021 Accepted 01 November 2021 Published 22 November 2021 Volume 8 - 2021 Edited by Marc Diederich, Seoul National University, South Korea Reviewed by Dan Herschlag, Stanford University, United States Adrian Drazic, University of Bergen, Norway Updates Copyright 2021 Mannervik, Ismail, Lindstrm, Sjdin and Ing
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