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Two other pharmaceutical companies have their own oral GLP-1 drugs in the works: Orforglipron: Developed by Eli Lilly, its in Phase 3 clinical trials for treating type 2 diabetes and obesity, with an expected September 2025 completion

Probiotic supplementation theoretically supports microbial diversity, though clinical evidence specific to GLP-1 tolerability remains emerging rather than definitive

174,175 Acute liver injury induced by carbon tetrachloride leads to activation of the Wnt/-catenin signalling pathway, which manifests as an increase in the level of the Wnt target gene AXIN2

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