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Retatrutide titration schedule in the combination The retatrutide titration in a combination protocol follows the same fundamental escalation pattern as monotherapy, but with two important modifications

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Briefly, cells expressing the corresponding D2-like receptors were treated with the agonist for 15 min (initial treatment) to trigger desensitization and then washed three times with serum-free medium (5 min per wash) at 37 C to remove the receptor-bound agonist