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The approval was based on OASIS 4 trial (307 patients): 16.6% mean weight loss with once-daily oral semaglutide 25 mg Weight loss comparable to injectable Wegovy 2.4 mg One in three patients achieved 20% weight loss Novo Nordisk plans a US launch in early January 2026, with EMA review already in progress

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This review summarizes the selected hormonal disturbances associated with white adipose tissue expansion