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Cardiovascular and Kidney Protection: Optimizing 'Energy Allocation Priority' Patients with cardiovascular disease and chronic kidney disease (CKD) often experience energy metabolism disorders, manifested as insufficient energy supply to myocardial and renal tissues, increased oxidative stress, and intensified inflammatory reactions

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Cannot increase to a higher dose Sometimes, people do not feel as much appetite reduction with semaglutide because they are not able to increase to a higher dose, or they may not tolerate higher doses due to side effects like nausea or stomach upset, says Karalis, RD