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Evidence from a multicenter, long-term cardiovascular outcome trial demonstrated that GLP-1RAs reduce mortality associated with cardiovascular disease and confer protective effects by decreasing the incidence of myocardial infarction and nonfatal stroke.104 GLP-1RAs have been shown to enhance endothelial cell function through anti-inflammatory and vasodilatory mechanisms

Non-surgical energy restriction for weight loss An overall healthy eating plan that results in an energy deficit, in conjunction with medications and/or metabolic surgery as individually appropriate, should be considered to support glycaemic and weight management goals in adults with type 2 diabetes [5, 22]

The most apparent effect for anyone taking them, though, is that the drugs slow gastric emptyingmaking food stay in the stomach longer and prolonging the full feeling it provides

While the effect is modest and transient, it represents another natural lever for supporting GLP-1 levels