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DeNicola et al, 2011

The SELECT study: a warning In 2023, semaglutide was shown to reduce the rates of major adverse cardiovascular events by 20% among persons with a history of atherosclerotic cardiovascular disease and obesity or in persons with overweight and one or more weight-related complications [79]

The researchers are planning a randomized trial to test whether benefits extend beyond weight to cardiovascular and metabolic markers

Baseline kidney function testing before initiating either substance, with periodic monitoring based on individual risk factors, represents prudent clinical practice, particularly in patients with diabetes or other kidney disease risk factors