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Factors such as polymerization shrinkage of composite resin materials, mechanical stress, and adhesive degradation can lead to microgaps forming between the restoration and the tooth structure ( Early efforts to extend the service life of dental composites centered on enhancing their mechanical properties and minimizing polymerization shrinkage ( Therefore, this paper reviews the latest progress of controlled-release antimicrobial nanomaterials (as summarized in Table 1 ) in preventing and treating secondary caries from the perspective of the strategy mechanism

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