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Only male mice were used in this study to minimize variability associated with the estrous cycle and because male db/db mice exhibit more severe and consistent hyperglycemia

Tilstra, J

Monti and colleagues in Uruguay ran a double-blind crossover of 25 nmol/kg over four nights and found that although several sleep measures moved in the expected direction, none differed significantly from baseline or placebo, and where differences did reach significance for NREM and stage 2 sleep, the same differences already existed at baseline

The Gallup poll also found that the percentage of Americans with obesity decreased from 39.9% in 2022 to 37.0% in 2025, a three-percentage-point decrease that represents 7.6 million people