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Conditions or therapies that predispose to acidosis (i.e., renal disease, severe respiratory disorders, status epilepticus, diarrhea, surgery, or ketogenic diet) may be additive to the bicarbonate lowering effects of phentermine and topiramate extended-release

Firth (1993) profile penalized log likelihood approach was adopted to obtain robust parameter estimates in the presence of rare events such as the present dataset

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And that's what I love about you, is that you have friends in both camps, and you're willing to trudge forward