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The downstream effects in pancreatic -cells include enhanced insulin synthesis and secretion, while in -cells, GLP-1R activation reduces glucagon secretion

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The fatal outcomes occurred mainly among men (8 out of 9) due to completed suicidal attempts and depression in Tables 2 and 3 respectively

Markers of protein oxidation (protein carbonyl glutamic [GSA] and aminoadipic [AASA] semialdehydes), glycoxidation (carboxyethyl-lysine [CEL], carboxymethyl-lysine [CML] and carboxymethyl-cysteine [CMC]), lipoxidation (malondialdehyde-lysine [MDAL]) and mitochondrial stress (2-succinyl-cysteine [2SC]) were identified as trifluoroacetic acid methyl ester derivatives in acid hydrolyzed delipidated and reduced plasma protein samples by GC/MS