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How does GLP help with weight loss

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The weight loss efficacy of tirzepatide alone raises an important question that anyone considering adding phentermine should seriously contemplate: with 15-21% average weight loss as monotherapy, do you actually need a second medication

Conversely, individuals with obesity show increased oxygen consumption in the insula, operculum, bilateral precuneus, and posterior cingulate cortex, along with the ventral putamen and Rolandic operculum, but decreased oxygen uptake in the lower caudatepatterns associated with increased impulsivity towards food stimuli (128130)