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Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria)

[DOI] [PubMed] [Google Scholar] 200.Stefan M, Murray R

NDA submission expected Q4 2026

However, IDPs exhibit characteristic values of specific heat capacity C p , which are elevated at all temperatures due to greater solvent-exposed surface area, and which exceed the C p values of folded proteins, and in the case of extensively disordered proteins, reaching the values characteristic for fully unfolded protein (Privalov and Makhatadze, 1990)