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Clinical studies of GLP-1RAs generally do not demonstrate sustained increases in resting energy expenditure, reinforcing the view that appetite suppressionnot thermogenesisis the dominant driver of weight loss ( Importantly, the physiological ceiling on BAT-mediated thermogenesis implies that increasing energy expenditure is unlikely to offset the metabolic adaptation associated with rapid weight loss

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In a subset of Phase 2 participants who underwent MRI imaging, liver fat was reduced by an average of 44% by week 24