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To establish the functional significance of these findings, we next tested the ability of GLP-1(2836) to prevent cytotoxicity in an in vitro model of oxidative stress (38)

In experimental models, mTOR inhibition promotes autophagy, enhances cellular stress resistance, and supports vascular healthfunctions that are progressively impaired in the aging brain

Relevant studies have found that exendin-4 could mediate the neuroprotective effect on -aminobutyric acid neurons in the piriform cortex and striatum and play a neuroprotective role in a cAMP/PKA- and PI3K/AKT-dependent manner after stroke (84, 85)