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Cureus 15(10) Miranda S et al (2025) Impact of semaglutide on lipid profiles in overweight and obese non-diabetic adults: a systematic review and meta-analysis of randomized controlled trials

In an experimental model of abdominal aortic aneurysm, topiramate markedly downregulated pro-inflammatory M1 macrophage activity, reduced the expression of TNF-, IL-1, and matrix metalloproteinase-9, and promoted a phenotypic shift of macrophages from M1 to M2, thereby mitigating pro-inflammatory activity and enhancing tissue repair processes ( These studies collectively suggest that topiramate exerts significant neuroprotective effects across various pathological models through its potent anti-inflammatory properties

Cell Metab (2012) 15:81326

Many of the interventions we discussed can have potentially dangerous effects of done without proper supervision