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Genetic Insights for Personalizing GLP-1 Therapy in Autoimmune Thyroid Disease The GLP1R gene variant rs6923761 influences how efficiently individual bodies respond to GLP-1 receptor agonists, meaning some patients achieve weight loss and metabolic benefits at lower doses while others may need higher doses for the same effect

77 Compared with GLP-1, the C-terminus of its amino acid sequence contains 9 additional amino acid residues (PSSGAPPPS), which are not easily degraded by peptide chain endonucleases